Photodynamic therapy generated oxidative stress for temporal and selective expression of heterologous genes
CA 2283108 A1 · Owner: Wong, Sam Keng Sum · Inventors: Nehme, Angela Ferrario; Wong, Sam Keng Sum; Luna, Marian Coensgen
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention describes a method for the selection and temporal expression of heterologous genes. The invention consists of methods to obtain selective and temporal expression of heterologous genes in target tissues. Promoters inducible by photodynamic therapy or heat are used to express genes of interest under conditions of heating or Photodynamic Therapy-(PDT-) induced oxidative stress. Selective and temporal expression of heterologous genes (such as cytokines, toxins, tumor suppressor genes antisense molecules and , anti-angiogenic factors) are of significant therapeutic benefit in the treatment of tumors, vascular proliferation and tissue hypertrophy. Gene therapy …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 9, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 9, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 9, 2020.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.