3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositionscomprising the same

Abstract From the Canadian patent

3-Piperidyl-4-oxoquinazoline derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof wherein R represents amino , substituted by optionally substituted aryl or optionally substituted heteroaryl, or cyclic amino such as dibenzazepine; n is an integer selected among 1 to 4; and R3 and R4 represent each hydrogen lower alkyl, etc. Because , of having an excellent MTP-inhibitory activity these compounds (I) are , expected as usable in inhibiting the formation of LDL causative of arteriosclerotic diseases and enabling the regulation of TG cholesterol and , lipoproteins such as LDL in the blood and cellular lipids via the regulation of the MTP activity. …