4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives, their preparation and their use as dopamine autoreceptor (d2) agonists

Abstract From the Canadian patent

Disclosed are compounds of formula (I) wherein R1 is hydrogen or C1-C6 alkyl; R2 is selected from hydrogen, straight-chain and branched C1-C10 alkyl cyclohexylmethyl or -(CH2)mAr where Ar is phenyl naphthyl, thienyl, furanyl , or pyridinyl each optionally substituted by one or two substituents selected independently from C1-C6 alkyl, halogen C1-C6 alkoxy and trifluoromethyl; or , NR1R2 is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2yl; m is 1-5; n is 1 or 2; R3 is hydrogen or C1-C6 alkyl; Y is halogen C1-C6 , alkyl, and C1-C6 alkoxy; or a pharmaceutically acceptable salt thereof which , are dopamine autoreceptor agonists and as such are useful in the treatment of …