4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-thiones derivatives, their preparation and their use as dopamine autoreceptor (d2) agonists

Abstract From the Canadian patent

This invention relates to a novel series of compounds having potency at the dopamine D2 receptor which are illustrated by formula (I) wherein R1 is hydrogen or C1-C6 alkyl; R2 is hydrogen or C1-C6 alkyl; R3 is selected from hydrogen, straight-chain and branched alkyl group having up to 10 carbon atoms, cyclohexylmethyl or -(CH2)mAr where Ar is phenyl naphthyl, thienyl, furanyl or pyridinyl each optionally substituted by one or two substituents selected independently from C1-C6 alkyl halogen, C1-C6 alkoxy and , trifluoromethyl; or NR2R3 is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4tetrahydroisoquinolin-2-yl; m is 1-5; n is 1 or 2; Y is halogen C1-C6 alkyl, and C1-C6 alkoxy; or a …