Surrogate genetics target characterization method

Abstract From the Canadian patent

A two-step, scalable method is described for identifying the cellular function(s) of one or more genes of unknown function and for identifying , modulators or the gene(s). The method uses the reversal or alteration of a phenotype created by the expression of the heterologous gene e.g. a human , gene, to identify modulators of that gene's activity. That modulator is then used in an in vitro or in vivo disease model system to identify compounds which affect disease progression. The subset of compounds which influence disease in a therapeutic manner are drug leads. However all compounds which , influence disease progression are tools to at least partially characterize gene function. The …