Method for measuring de novo t-cell production in humans
CA 2277089 A1 · Owner: Institut De Recherches Cliniques De Montreal · Inventors: Poulin, Jean-Francois; Komanduri, Krishna V.; Mccune, Joseph M.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to a method for measuring de novo T-cell production in humans and more, particularly to the assessement recent thymic emigrant (RTE) diversity in a T-cell sub-population of a patient by the detection of T-cell receptor .beta. chain DNA deletion circles (TCR.beta.DC) generated during TCR gene rearrangement of thymocytes in the thymus. The method comprises isolating a T-cell sub-population from a patient, extracting genomic DNA from the T-cell sub-population, amplifying the genomic DNA with a primer specific for a T-cell receptor .beta. chain DNA rearrangement deletion circle (TCR.beta.DC) family and detecting the TCR.beta.DC, the TRC.beta.DC being indicative of …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 30, 1999. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended June 30, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 30, 2021.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.