Bioreactive allosteric polynucleotides

Abstract From the Canadian patent

Polynucleotides having allosteric properties that modify a function or configuration of the polynucleotide with a chemical effector and/or physical signal are employed primarily as biosensors and/or enzymes for diagnostic and catalytic purposes. In some preferred embodiments the polynucleotides are DNA , enzymes that are used in solution/suspension or attached to a solid support as biosensors to detect the presence or absence of a compound its concentration, or physical change in a sample by observation of self-catalysis. Chemical effectors include organic compounds such as amino acids amino acid , derivatives, peptides, nucleosides nucleotides, steroids, and mixtures of these with …