Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
CA 2273194 C · Owner: Klapholz, Sue · Inventors: Mendez, Michael; Jakobovits, Aya; Green, Larry
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular animals , in accordance with the invention possess human Ig loci that include plural variable (VH and V) gene regions. Advantageously the inclusion of plural , variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further the inclusion of such regions , enhances and reconstitutes B-cell development to the animals such that the , animals possess abundant mature B-cells secreting extremely high affinity antibodies.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 3, 1997 and granted February 1, 2011. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended December 3, 2017.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 3, 2019.
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Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.