Mammalian rad1 genes, polypeptides and methods of use

Abstract From the Canadian patent

The present invention provides isolated nucleic acid molecules encoding mammalian RAD1p polypeptides (such as human and marine RAD1p polypeptides) and allelic variants, mutants fragments or derivatives thereof. , The invention also provides mammalian RAD1p polypeptides encoded by such isolated nucleic acid molecules, antibodies binding to such polypeptides genetic, constructs comprising such nucleic acid molecules prokaryotic or eukaryotic , host, cells comprising such genetic constructs and methods and compositions for use, in diagnosing and treating disorders characterized by or utilizing, a loss of , cell, cycle checkpoint control or by increased sensitivity to DNA-damaging agents.