3-substituted pyrido(4',3':4,5)thieno(2,3-d)pyrimidine derivatives, their preparation and their use

Abstract From the Canadian patent

The invention concerns 3-substituted 3,4,5,6,7,8-hexahydropyrido4,3':4,5thieno-2,3-dpyrimidine derivatives of formula (I) in which: R1 designates a hydrogen atom, a C1-C4 alkyl group an acetyl or benzoyl , group, a phenylalkyl C1-C4 group - the aromatic optionally being substituted by halogen, C1-C4 alkyl, trifluoromethyl hydroxy, C1-C4 alkoxy, amino, cyano , or nitro groups - a naphthylalkyl C1-C3 group a phenylalkanone C2-C3 group or , a phenylcarbamoylalkyl C2 group wherein the phenyl group can be substituted by halogen; R2 designates a phenyl, pyridyl pyrimidinyl or pyrazinyl group , which can optionally be monodi- or tri-substituted by halogen atoms C1-C4 , alkyl, trifluoromethyl, …