Humanized immunoglobulin reacting specifically with fas ligand or active fragments thereof and region inducing apoptosis originating in fas ligand

Abstract From the Canadian patent

A novel humanized immunoglobulin reacting specifically with a Fas ligand and active fragments thereof are provided and a region on a Fas ligand which is important in inhibiting apoptosis induced by cells with Fas expression on the basis of the Fas-Fas ligand interaction is clarified. The novel humanized immunoglobulin and active fragments thereof are prepared by the recombinant DNA techniques from hybridomas which produce a monoclonal antibody reacting specifically with a Fas ligand. This immunoglobulin can inhibit physiological reactions between a Fas ligand and Fas typified by apoptosis. By specifying , the region participating in the induction of apoptosis on a Fas ligand there , …