Inhibition of blood platelet aggregation in blood exposed to a foreign body by a polymer coating on the surface thereof containing a nitric oxide-releasing nitrosyl-containing organometallic compound and foreign bodies thus coated

Abstract From the Canadian patent

The aggregation of platelets on the surface of a foreign body exposed to the flowing blood of a living being (such as plastic tubing a balloon or the end , of a catheter surgically inserted in a blood vessel a stent implanted therein , or synthetic grafts which surface normally promotes such platelet aggregation to form a coating firmly affixed to that surface which would restrict the flow of blood past that surface or to form a blood clot detachable from that surface), is inhibited by a gas permeable coating on the surface of a physiologically acceptable polymer as which contains dissolved or dispersed therein a nitrosyl-containing organometallic compound such as sodium , …