Homologous recombination in mismatch repair inactivated eukaryotic cells
CA 2263958 C · Owner: De Wind, Niels · Inventors: Te Riele, Henricus Petrus Joseph; De Wind, Niels; Dekker-Vlaar, Helena Maria Johanna
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to a method for modifying the genome of eukaryotic cells by homologous recombination using DNA sequences which substantially differ from the target locus with respect to the nucleotide sequence (0.1 to 30 % divergence) in the region where recombination takes place. Homologous recombination between diverged sequences is achieved by genetic or transitory inactivation of the cell's mismatch repair system.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed July 26, 1995 and granted June 19, 2012. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended July 26, 2015.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by July 26, 2017.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.