Fusion polypeptides comprising an ige-binding domain and a hsa component, and their diagnostic and therapeutic uses

Abstract From the Canadian patent

Fusion polypeptides and salts thereof comprising at least one IgE-binding domain fused to at least one human serum albumin component optionally via a , peptide linker, and in particular dimeric fusion polypeptides comprising HSA protein fused, at each of its amino and carboxy termini to an extracellular , domain of the .alpha.-chain of the human high affinity receptor for IgE (Fc.epsilon.RI.alpha.); process for the preparation thereof functionally , equivalent polypeptides which are intermediates in their preparation and , polynucleotide and oligonucleotide intermediates and vectors therefor. They are indicated for use in the prevention and/or treatment of IgE-mediated allergic …