Benzimidazole cyclooxygenase-2-inhibitors

Abstract From the Canadian patent

This invention provides a compound of the following formula: (see fig. I), or the pharmaceutically acceptable salts thereof preferably wherein, Ar is heteroaryl; X1 and X2 are independently selected from halo C1-C4 alkyl, hydroxy, C1-C4 alkoxy, amino C1-C4 alkanoyl, carboxy, carbamoyl, cyano nitro, mercapto, (C1-C4 alkyl)thio, (C1-C4 alkyl)sulfinyl (C1-C4 alkyl)sulfonyl, aminosulfonyl, or the like; R1 is selected from hydrogen straight or branched , C1-C4, alkyl, C3-C8 cycloalkyl C4-C8 cycloalkenyl, phenyl , heteroaryl and the like; R2 and, R3 are independently selected from hydrogen halo, C1-C4 alkyl, phenyl and the , like; or R1 and R2 can form, together with the carbon atom to which …