5-substituted picolinic acid compounds and their production process

Abstract From the Canadian patent

The present invention provides novel 5-substituted picolinic acid compounds of formula (I) or a pharmaceutically acceptable salt thereof: (see fig. I), wherein R1 and R2 are independently H C2-C6 acyl or halo-substituted benzoyl; and R3 is -C(O)O-C1-C6 alkyl, C(O)OH, CN, CONH2 CONHCH3, CON(CH3)2, 1-methyltetrazole or 2-methyltetrazole with the proviso that when R2 is acetyl and R3 is methoxycarbonyl, R1 is not H; and that when R3 is CN CONH2, CONHCH3, CON(CH3)2, 1-methyltetrazole or 2-methyltetrazole R1 and R2 are H. The present invention also relates to a pharmaceutical composition comprising compound of the present invention which is useful in the treatment of, IL-1 and TNF mediated …