Human netrin-1

Abstract From the Canadian patent

Specific netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant netrin protein a natural , intracellular netrin protein binding target and a candidate pharmacological agent; incubating the mixture under conditions whereby but for the presence , of said candidate pharmacological agent said netrin protein selectively binds said binding …