Amphipathic molecules as cholesterol and other lipid uptake inhibitors

Abstract From the Canadian patent

Cholesterol biosynthesis can be inhibited by suitable inhibitors such as the , statins. However, hypercholesterolaemia whether familial or diet-induced, and more generally hyperlipidaemia are not adequately addressed by cholesterol biosynthesis inhibitors alone, since the body's cholesterol is acquired by uptake from the diet as well as by endogenous synthesis. Lipid is also taken up from the gut. This problem is addressed by providing one or more molecules having amphipathic regions to inhibit the uptake of cholesterol and other , lipids, from the gut. Obesity may also be treated or prevented in this way as , may atherosclerosis. Examples of suitable molecules having amphipathic …