Method for docetaxel synthesis
CA 2246327 A1 · Owner: Swindell, Charles S. · Inventors: Swindell, Charles S.; Sisti, Nicholas J.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method of producing docetaxel comprises the esterification of C7 C10 di-CBZ , 10-deacetyl baccatin III and an N-CBZ C2'-protected 3-phenyl isoserine side chain wherein C2' is protected by a hydrogenatable benzyl-type protecting group. The C7, C10 carbobenzyloxy groups are then replaced with hydrogen and the carbobenzyloxy group at the C3' nitrogen site is replaced with <u>t</u>butoxycarbonyl. Finally, the resulting compound is deprotected at C2' by replacing the benzyl-type protecting group with hydrogen to produce docetaxel. The esterification preferably employs an excess such as six equivalents, of , the side chain for each equivalent of the C7 C10 di-CBZ 10-deacetyl baccatin , …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 19, 1997. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 19, 2017.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 19, 2019.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.