A process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid derivatives
CA 2244884 A1 · Owner: Dibra S.P.A. · Inventors: Desantis, Nicola
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to a process for the preparation of non-ionic iodinated contrast media derivatives of 5-amino-1,3-benzenedicarboxylic acid and having a hydroxy-substituted acylamino residue at the 5-position comprising the following steps without isolating any intermediate: a) reacting 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride with an acyl chloride, containing hydroxy groups protected as ester to give a solution of , 5-acylamino-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride in dimethylacetamide; b) adding the crude solution resulting from step a) with a tertiary amine of formula NR1R2R3, wherein R1 R2, R3 are independently a (C1-, C12) …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 1, 1997. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended December 1, 2017.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 1, 2019.
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Timeline
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Sources & verification
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.