Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agents
CA 2244746 A1 · Owner: Schering Aktiengesellschaft · Inventors: Graf, Hermann; Neef, Gunter; Klar, Ulrich
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
There are described taxanes of general formula (I) wherein Sk may be (i), R1 , may be hydrogen or C1-C10 acyl R2 may be .alpha.-OH or .beta.-OH, R3 may be C1-C10 alkyl, X-substituted phenyl, C1-C10 alkoxy X may be hydrogen, halogen, -N3 or -CN and free hydroxy groups in (I) may be functionally modified further by etherification or esterification and also the .alpha.-, .beta.- , and .gamma.-cyclodextrin clathrates thereof and also compounds of general , formula (I) encapsulated with liposomes. The compounds of formula (I) according to the invention, compared with taxol have an advantageously , altered activity profile. In addition to a clearly improved stabilisation of microtubules, the …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed January 31, 1997. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended January 31, 2017.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by January 31, 2019.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.