Inhibitors of farnesyl protein transferase

Abstract From the Canadian patent

This Invention relates to compounds that inhibit farnesyl-protein transferase and ras, protein farnesylation, thereby making them useful as anti-cancer agents. The compounds, are also useful 1n the treatment of diseases other than cancer, associated , with signal transduction pathways operating through ras and chose associated with proteins other than, ras that are also post-translationally modified by the enzyme farnesyl protein transferase. The compounds may also act as inhibitors of other prenyl transferases and , thus be effective, in the treatment of diseases associated with other prenyl modifications of proteins. The, compounds of the invention are of formulas I I I, I Il and IV.