Stable biotinylated biomolecule composition and methods

Abstract From the Canadian patent

Compositions and methods for biotinylated biomolecules such as enzymes, are , disclosed. The compositions include a biotinylated biomolecule a biomolecule , protectant, a buffer, a bulking agent selected from one or more water soluble nonionic polymers and preferably a terminal sterilization protectant. The compositions can be utilized either as aqueous solutions or preferably in dried form, e.g. as a lyophilized powder cake. They have applicability in any case wherein avidin/biotin technology is used and are particularly important , as compositions containing a thrombin-like enzyme. The preparation of a fibrin monomer and fibrin monomer-based fibrin sealants are an example wherein …