Process to chloroketones using oxazolines

Abstract From the Canadian patent

This invention relates to a process for the preparation of an .alpha.-chloroketone compound comprising the steps of, (i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline (see.fig.I), (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate (see fig.II), and, (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone (see fig.III), wherein, Z is alkyl or substituted alkyl aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene, R is a hydrogen atom or alkyl and, R1 and R2 are each independently an alkyl or substituted alkyl group or R1, and …