Sulfonamide-substituted fused 7-membered ring compounds, processes for their preparation, their use as a medicament or diagnostic, and pharmaceutical preparations comprising them

Abstract From the Canadian patent

Sulfonamide-substituted fused 7-membered ring compounds processes, for their preparation, their use as a medicament or diagnostic and, pharmaceutical preparations comprising them The present invention relates to compounds of the formula I (see Fig.I), in which X1, X2, X3, X4, Y1 Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the claims, their preparation and their use in, particular in pharmaceuticals. The compounds effect the potassium channel or the IKs channel opened by cyclic adenosine monophosphate (cAMP) and are outstandingly suitable as pharmaceutical active compounds, for example for the prophylaxis and therapy of cardiovascular disorders, in particular arrythmias, …