Process for preparing quinazolin-4-one derivative

Abstract From the Canadian patent

The present invention provides a novel process for preparing a series of quinazolin-4-one derivatives in high yields with reduced amounts of byproducts the, process comprising reacting, in the presence of a base a, trialkylsilyl halide with a compound represented by the formula, (see formula I), wherein R1, R2 R3 and R4 are the same or different and each represent a hydrogen atom, a lower alkyl group a, halogen atom, a nitro group, a lower alkoxy group a, cyano group, an N-lower alkylcarbamoyl group a lower, alkoxycarbonyl group, a lower alkanoyloxy group or a halogen-substituted lower alkyl group; R5 is a phenyl group which may have 1 to 3 substituents each selected from a lower alkyl …