Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use
CA 2227159 A1 · Owner: Muller, Rolf · Inventors: Heidtmann, Hans Heinrich; Sedlacek, Hans-Harald; Muller, Rolf
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention relates to a nucleic acid construct for expressing an active substance which is activated by an enzyme which is released from mammalian cells, which construct comprises the following components: a) at least one promoter element, b) at least one DNA sequence which encodes an active compound (protein B), c) at least one DNA sequence which encodes an amino acid sequence (part structure C) which can be cleaved specifically by an enzyme which is released from a mammalian cell and, d) at least one DNA sequence which encodes a peptide or protein (part structure D) which is bound to the active compound (protein B) by way of the cleavable amino acid sequence (part structure C) and …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed January 16, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended January 16, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by January 16, 2020.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.