Process for preparing derivatives of azabicyclo naphthyridine carboxylic acid comprising a dipeptide
CA 2224616 C · Owner: Castaldi, Michael J. · Inventors: Castaldi, Michael J.; Braish, Tamim F.; Watson, Harry A. Jr.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A novel process for preparing a prodrug acid viz. 7-(1.alpha. 6.alpha. 7.alpha.)-6-(L-Ala-L-Ala-amino)-3-azabicyclo3.1.0hex-3-yl-6-fluoro-1-(2,4difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid in the , form of a pharmaceutically acceptable acid addition salt is disclosed, which , involves (1) treating an N-protected 7-(1.alpha. 5.alpha. 6.alpha.)-6-amino- 3-azabicyclo3.1.0hex-3-yl-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo- 1,8-naphthyridine-3-carboxylic acid C1-C4 alkyl ester wherein the nitrogen-, protecting group is benzyloxycarbonyl C1-C4 alkoxycarbonyl or C1-C4 alkanoyl with a strongly-protic acid to selectively remove the N-protecting group; (2) then …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
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- Filed March 27, 1996 and granted May 2, 2000. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended March 27, 2016.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 27, 2018.
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