Conformationally-restricted combinatorial library composition and method
CA 2224086 C · Owner: Pence Inc. · Inventors: Hodges, Robert S.; Houston, Michael E. Jr.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Combinatorial libraries of different-sequence peptide members is disclosed. The libraries are comprised of stabilized alpha-helical polypeptides having a , similar tertiary structure but different amino acid residues at specific "variable" positions in the sequence. The polypeptides are stabilized through coiled-coil interactions with other .alpha.-helical polypeptides and/or via intrahelical lactam bridges. Also disclosed are methods for using such libraries to screen for selected macromolecular ligands.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 14, 1996 and granted November 20, 2001. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended June 14, 2016.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 14, 2018.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.