Process for the preparation of 1,2-dioxetane compounds and novel sulfur-substituted 1,2-dioxetane compounds as intermediates

Abstract From the Canadian patent

A process is provided for the preparation of a variety of triggerable dioxetanes bearing alkoxy, alkenyloxy, alkynyloxy arlyoxy, aralkyloxy or , acyloxy substituents from a common intermediate along with sulfur-substituted dioxetanes and vinyl sulfide compounds used as intermediates. Alkoxy alkenyloxy, alkynyloxy, arlyoxy, aralkyloxy or acyloxy substituted dioxetanes are useful in detecting activating agents and in assays such as immunoassays and nucleic acid hybridization assays. The sulfur-substituted dioxetanes additionally are useful for producing chemiluminescence. The novel process involves conversion of a vinyl sulfide compound to a sulfur-substituted dioxetane, reacting the …