Novel substituted taxanes and pharmaceutical compositions containing them

Abstract From the Canadian patent

The invention relates to a .beta.-lactam of the formula (see fig. I), wherein, R1 and R3 are independently selected from phenyl naphthyl, C6H5CHCH-, and, (see fig. II) (see fig. III) or (see fig. IV), Q is CH3- (CH3)3C-, CH3)-, Cl, Br, F, or NO2; and R2 is hydrogen or hydroxy protecting group. The .beta.-lactams are useful as intermediates in the preparation of a taxane derivative of the formula, (see fig. IV) wherein, R1 and R3 are independently selected from the group comprising phenyl, naphthalene, C6H5CHCH- (see fig. V), (see fig. VI) and (see fig. VII) provided, however, R1 and R3 are not both phenyl; Q is CH3-, (CH3)3C-, CH3O-, Cl, Br, F, or NO2; Z is -OT1;, T1 is hydrogen, hydroxyl …