Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents

Abstract From the Canadian patent

Compounds useful, as cytoprotective agents of formula (I), wherein z, =(a) and (b); n = 0-12; m = 0-12; X = nothing, NR1, O, or S(O)n'; provided that when X = NR1, O, or S(O)n', then m>0 and n>0; n' = 0-2; R1 = H, C1-C6 alkyl; R = OH or a pharmaceutically, acceptable salt thereof C1-C6 alkoxyl, amino, mono- or dialkylamino where the alkyl has from, 1 to 4 carbon atoms or a, radical of an amino acid, of the formula: -NH- (CH2)n-CH(R2) CO-R3;, R2 = H, C1-C4 alkyl optionally substituted by, hydroxy, SH SCH3, or, (un)substituted phenyl; and, R3 = OH C1-C6 alkoxyl, amino, or mono- or dialkyl amino where the alkyl has from 1 to 4 carbon atoms. The compounds possess dual activity, containing a …