Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs

Abstract From the Canadian patent

Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising: (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates transfers or , releases a nitrogen monoxide group (preferably as a charged species particularly nitrosonium); and methods of treatment of inflammation pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal renal and , other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.