Methods of inducing immune tolerance using immunotoxins

Abstract From the Canadian patent

Provided is a method of treating an immune system disorder not involving T-cell proliferation comprising administering to the animal an immunotoxin comprising a mutant diphtheria toxin moiety linked to an antibody moiety which routes by the anti-CD3 pathway or derivatives thereof under conditions such that the disorder is treated. Thus the present method can treat graft-versus-host disease. Also provided is a method of inhibiting a rejection response by inducing immune tolerance in a recipient to a foreign mammalian donor tissue or cells comprising the steps of: a) exposing the recipient to an immunotoxin so as to reduce the recipients' peripheral blood T-cell lymphocyte population by at …