G2 checkpoint inhibitors and assay
CA 2216559 A1 · Owner: Andersen, Raymond · Inventors: Andersen, Raymond; Roberge, Michel; Anderson, Hilary J.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Compounds are provided that inhibit the G2 checkpoint in the cell cycle and are useful for sensitizing G1 deficient cancer cells to killing by DNA damaging agents. Also provided is an assay for G2 checkpoint inhibitors which includes applying a DNA damaging agent to p53 deficient cells and determining whether such cells do not arrest at G2 and proceed to mitosis after application of a sample to be tested. The assay may employ mitotic cell specific monoclonal antibodies. Compounds of this invention have the general formula:, wherein R5 is selected from the group comprising: ,
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed September 25, 1997. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended September 25, 2017.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by September 25, 2019.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.