Mercapto and seleno derivatives as inhibitors of nitric oxide synthase

Abstract From the Canadian patent

This invention is directed to a pharmacologically acceptable composition for inhibiting nitric oxide synthase in a mammal which includes a mercapto or , seleno derivative and a pharmaceutically acceptable carrier. The invention also concerns a method of inhibiting nitric oxide synthase selectively , inhibiting the inducible isoform of nitric oxide synthase and treating , various conditions where there is an advantage in inhibiting nitric oxide biosynthesis. The method includes the step of administering to a mammal a mercapto or seleno derivative in pure form or in a pharmaceutically acceptable carrier.