Piperidinylamino tricyclic compounds as substance p antagonists

Abstract From the Canadian patent

This invention provides a compound of the formula: (see fig. I ), and its pharmaceutically acceptable salts wherein, Ar1 is selected from groups of the following formulae: (see fig. II), (see fig.III), (see fig. IV) and (see fig V) ;, wherein, R1 and R2 are independently hydrogen or C1-C6 alkyl; W is (CH2)n wherein n is from 1 to 3, or -CH=CH-; X is C1-C6 alkoxy or halo C1-C6 alkoxy; and Ar2 is phenyl optionally substituted by halogen atom. These compounds are useful in the treatment of a gastrointestinal disorder a, central nervous system (CNS) disorder an inflammatory disease, emesis, urinary incontinence, pain, migraine, sunburn, angiogenesis diseases, disorders and adverse, conditions …