Energy transfer dyes with enhanced fluorescence

Abstract From the Canadian patent

Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer, of energy between a donor an acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl, attached to the donor dye, C(O) is a carbonyl group Z1 is either NH, sulfur , or, oxygen, R22 is a substituent which includes an alkene diene, alkyne, a five , and six, membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon and R28 …