Benzothiophenes, formulations containing same, and methods

Abstract From the Canadian patent

The present invention provides class of compounds of formula I, (See Fig. I), (I), and their pharmaceutically acceptable salts in which R1 is hydrogen, hydroxy, alkoxy, alkoxycarbonyloxy alkylcarbonyloxy, arylcarbonyloxy; R~ is hydrogen hydroxy, alkoxy, alkoxycarbonyloxy, alkylcarbonyloxy alkylsulfonyloxy, arylcarbonyloxy, Cl or Br; R3 and R4 are independently C1-C4 alkyl, or combine with the nitrogen atom to which they are attached to form a pyrrolidino piperidino, or hexamethyleneimino ring; X is selected from (See Fig. II, III, IV, V, VI, and VII) and Y is -CO-, -CHOH-, or -CH2-. The compounds and pharmaceutical compositions containing the compounds, either alone or in combination with …