Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them

Abstract From the Canadian patent

Ortho-substituted benzoylguanidines, process for their preparation their use as a, medicament or diagnostic and medicament comprising them, Ortho-substituted benzoylguanidines of the formula I (see fig. I), in which R(1) to R(4) have the meanings given in the claims are suitable, as, antiarrhythmic pharmaceuticals having a cardioprotective component for the, prophylaxis and treatment of infarction and for the treatment of angina pectoris. They also inhibit in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage in particular, associated with the triggering of ischemically induced cardiac arrhythmias.