3-(5-substituted benzyl)amino-2-phenylpiperidines as substance p antagonists

Abstract From the Canadian patent

This invention provides a compound of the formula: (see fig. I), (I), and its pharmaceutically acceptable salts wherein, R1 is C1-C6 alkyl, C3-C6 cycloalkyl halo C1-C6 alkyl or terahydropyranyl, having one or more substituents selected from cyano 1,3-thiazolanyl, COOR2, COR2, OCOR2, CONR3R4 NR3R4, NR5COR3 and CCR6, wherein R2 is hydrogen or C1-C4 alkyl, R3 and R4 are independently hydrogen C1-C4 alkyl or C3-C6 cycloalkyl, R5 is C1-C4 alkyl or C3-C6 cycloalkyl and R6 is hydrogen halo, cyano, C1-C6 alkyl, COOH, COO(C1-C4 alkyl) or phenyl; X is C1-C6 alkoxy or halo C1-C6 alkoxy; and Ar is phenyl optionally substituted with halo. These compounds are useful in the treatment of allergic disorders …