Use of a bacterial component to enhance targeted delivery of polynucleotides to cells
CA 2192687 C · Owner: Zhang, Ying · Inventors: Carmichael, Ellen; Wu, Catherine H.; Wu, George Y.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
An improved soluble molecular complex for targeting a polynucleotide to a specific cell is disclosed. The molecular complex comprises: (a) a polynucleotide; (b) a carrier made up of a polynucleotide binding agent and a cell-specific binding agent which binds to a surface molecule of the cell and is internalized into an endosome, and (c) a bacterial component or fragment thereof which lyses the endosome and causes the polynucleotide to be released into the cytoplasm of the cell. In a preferred embodiment of the invention the polynucleotide binding agent is polylysine the cell-specific binding agent is , an asialoglycoprotein and the bacterial component is listeriolysin O. The …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 27, 1995 and granted December 7, 1999. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended June 27, 2015.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 27, 2017.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.