Methods for modulating t cell responses by manipulating intracellular signal transduction
CA 2189055 C · Owner: United States Of America, Represented By The Secretary Of The Navy · Inventors: June, Carl H.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Methods for modulating T cell responses by manipulating intracellular signals associated with T cell costimulation are disclosed. The methods involve inhibiting or stimulating the production of at least one D3-phosphoinositide in a T cell. Production of D3-phosphoinositides can be manipulated by contacting a T cell with an inhibitor or activator of phosphatidylinositol 3-kinase. Inhibitors of phosphatidylinositol 3-kinase for use in the methods of the invention include wortmannin and quercetin or derivatives or analogues thereof. The methods of the invention can further comprise modulating other intracellular signals associated with costimulation such as protein tyrosine phosphorylation for …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed May 1, 1995 and granted January 18, 2011. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended May 1, 2015.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by May 1, 2017.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.