Tryptamine derivatives as 5-ht-1d receptor ligands

Abstract From the Canadian patent

Described herein are, tryptamine analogs that display high binding affinity and selectivity, for the 5-HT1D.beta. receptor of, formula (I), wherein R1 is a, group selected from aryl-C1-7alkyl; aryl-C2-7alkoxy; aryl-C2-7alkanoyl, and aryl-C1-7alkanoyloxy wherein, said alkyl, alkoxy, alkanoyl, and alkanoyloxy groups are optionally substituted by a C1-4alkyl, substituent and wherein said aryl group is optionally substituted by, one or more substituent selected from hydroxyl halogen, mercapto, linear or branched C1-4alkyl linear or branched C1-4alkoxy, linear, or branched C1-4alkylthio thiol substituted C1-4alkyl and nitro substituted C1-4alkyl; R and R3 are selected independently from H and …