Process for the purification and crystallisation of iopamidol
CA 2178369 C · Owner: Santos, Pedro Paulo De Lacerda E Oliveira · Inventors: Heggie, William; Santos, Pedro Paulo De Lacerda E Oliveira; Mendes, Zita Maria De Mouro Vaz Azevedo
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention describes a process for the purification and crystallisation of Iopamidol, wherein 1-propanol, or 2-propanol is added to an aqueous solution ofIopamidol followed if necessary, by azeotropic distillation to reduce the quantity of water in relation to the quantity of propanol and thereby ensure an high yield. The, aqueous solution can be prepared either by the dissolution of crude Iopamidol inwater or directly from the reaction in which the Iopamidol is formed. The present invention presents advantages for the routine production of Iopamidol since the crystallisation is straightforward to perform can be easily controlled and is, reproducible at an industrial scale.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 6, 1996 and granted October 16, 2001. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended June 6, 2016.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 6, 2018.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.