Novel process for preparing (s)-1-2(s)-(1,3-dihydro-1,3-dioxo-isoindo-2-yl)-1-oxo-3-phenylpropyl-1,2,3,4-tetrahydro-2-pyridine-carboxylic acid methyl ester and intermediates thereof
CA 2177044 C · Owner: Flynn, Gary A. · Inventors: Flynn, Gary A.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to a novel enantiospecific process for preparing (S)-1-2(S)-(1,3-dihydro-1,3-dioxo-isoindo-2-yl)-1-oxo- 3-phenylpropyl-1,2,3,4-tetrahydro-2-pyridine-carboxylic cid methyl ester (I)which is a usefull intermediate in the preparation of 4S- 4.alpha.?.alpha.(R*),12b.beta.-7-(1-oxo-2(S)-thio-3-phenylpropyl)amino-1,2,3,4,6,7,8,12b-octahydro-6-octahydro-6-oxo-pyrido2,1-a2benzazepine-4-carboxylic acid and 4S-4.alpha. 7.alpha.(R*), 12b.beta.-7-1-oxo-2(S)-acetylthio-3-phenylpropyl)amino-1,2,3,4,6 7,8,12b-octahydro-6-oxo-pyrido2,1a2benzazepine-4-carboxylic acid and pharmaceutically acceptable salts thereof which is useful as an inbibitor of enkephalinase and angiotensin …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 20, 1994 and granted June 1, 1999. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended October 20, 2014.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 20, 2016.
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