3-aryl-4-alkyl and 4,5-dialkyl-4h-1,2,4-triazoles useful as memory enhancers

Abstract From the Canadian patent

This invention relates, to the enhancement of memory and cognition, and the treatment of Alzheimer's disease and, Wernicke-Korsakoff syndrome by administration, of 3-aryl-4-alkyl and 4,5dialkyl-4H-1,2,4-triazoles, of formula (I) wherein R1 and R2 independently represent hydrogen halogen, trifluoromethyl, nitro, C1-4 lower alkyl or C1-4 lower alkoxy or together, R1 and R2, represent -CH=CH-CH=CHforming a 1- or 2-naphthylenyl ring system; R3 represents hydrogen or C1-4 lower alkyl; and R4 represents C1-4 lower alkyl, benzyl, or benzyl substituted by one or two groups selected from halogen trifluoromethyl, nitro, C1-4 lower alkyl or C1-4 lower alkoxy.