Methods for screening for regulators of intracellular receptor transcription using progesterone receptor a subtype
CA 2174416 A1 · Owner: Ligand Pharmaceuticals Incorporated · Inventors: Mcdonnell, Donald P.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Methods to screen for antagonists of steroid IR transcription as mediated by the PR-A isoform of the progesterone receptor are provided. Such cell-based methods include a cell in which PR-A is transcriptionally inactive containing a steroid IR other than PR PR-A, and a reporter vector that includes a promoter which is transcriptionally active in the presence of the steroid IR and an activator of said steroid IR, but is substantially transcriptionally inactive in the presence of PR-A. This cell is contacted with the activator of the steroid IR and a compound to be assayed, and the level of reporter product produced in the cell is measured and compared to the level of reporter product …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 5, 1994. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 5, 2014.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 5, 2016.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.