Use of anti-idiotypic antibodies to prevent hyperacute rejection of xenografts

Abstract From the Canadian patent

Antibodies directed against idiotypes on naturally occurring human anti-animal antibodies are disclosed for use in inhibiting xenograft rejection in human patients. An effective quantity of these anti-idiotypic antibodies is injected into the actual or potential xenograft recipient in order to bind to the idiotypes expressed on anti-animal antibodies as well as subpopulations of B lymphocytes to inhibit hyperacute, rejection of transplanted animal tissues or organs by the human patient. Alternatively anti-idiotypic antibodies are used in the form of immunoaffinity columns to deplete anti-animal antibodies from the recipient's serum. Methods of making mouse monoclonal mouse, recombinant , …