Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension

Abstract From the Canadian patent

The present invention involves a method for prophylaxis or treatment of an animal for systemic hypotension induced by endotoxin and/or a biological response modifier such as the cytokines IFN, TNF, IL-1 or IL-2 and the like. Said method involves administering, preferably intravascularly a therapeutically effective amount , of dobutamine and an inhibitor of nitric oxide formation from arginine. Although preferable administration is intravascular it is, contemplated that other parenteral administration routes such as intraperitoneal, intramuscular or subdermal injection for, example, may prove useful. Enteral or topical administration of arginine analogs may also prove beneficial under …